The Bomber takes on the Ukranian at the Manchester Arena on Saturday night, in what will surely be his final fight.
The prize on the line is the undisputed cruiserweight championship, a title Usyk currently holds.
This will be the second time Bellew has fought for a cruiserweight world title, as he previously held the WBC crown after defeating Illunga Makabu in 2016.
Whilst the odds are stacked against Bellew, he is adamant he can pull off the upset and take home the titles.
His trainer, Dave Coldwell, explained the way Bellew can win on Saturday night, whilst admitting he was emotional about the Evertonian training with him for the final time.
“It’s the end of a great era,” Coldwell said.
“I don’t know what Usyk is planning.
“Look at his fights.
“Sometimes he fights coming forward, sometimes he fights on the back foot, so you have to prepare for both.”
Bellew goes into the fight on Saturday as a 4/1 underdog against the unbeaten champion.
However, both he and Coldwell are confident of pulling off a result in his final fight.
And the trainer explained that Bellew must listen to his every command if he is to get the win, and force Usyk into uncomfortable waters.
“The most important thing is that Tony Bellew, or any of my fighters, has to implement what I want them to do,” Coldwell added.
“To get the best out of them, they have to make the opponent adjust to you.”
Bellew has declared that Saturday will be his final fight before retiring, whilst Usyk is also unlikely to fight at cruiserweight again.
The Ukranian has revealed his intentions to move up to heavyweight and challenge for world title belts at that level.